Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women
Kelly E. Mercer, Adrianna Maurer, Lindsay Pack, Kikumi D. Ono‐Moore, Beverly J. Spray, Caitlin Campbell, Carol J. Chandler, Dustin J. Burnett, Elaine C. Souza, Gretchen A. Casazza, Nancy L. Keim, John W. Newman, Gary R. Hunter, Jose Fernadez, W. Timothy Garvey, Mary‐Ellen Harper, Charles L. Hoppel, Sean H. Adams, John P. Thyfault
Abstract
Exercise and weight loss in previously sedentary, insulin-resistant women facilitates a significant improvement in insulin sensitivity and fitness that may be linked to changes in bile acid metabolism. Diet-induced weight loss plus exercise-induced increases in fitness promote greater postabsorptive bile acid synthesis while also sensitizing the bile acid metabolic system to feedback inhibition during a glucose challenge when glucose and insulin are elevated.