A Janus 3D DNA nanomachine for simultaneous and sensitive fluorescence detection and imaging of dual microRNAs in cancer cells
Zezhou Yang, Xin Peng, Peng Yang, Ying Zhuo, Yaqin Chai, Wenbin Liang, Ruo Yuan
Abstract
hybridization (FISH) approach. Therefore, it could serve as persuasive evidence for supplying accurate information to better understand biological processes and investigate mechanisms of various biomolecules and subcellular organelles, resulting in the further validation of their function in tumor proliferation and differentiation. This strategy provided an innovative approach to design new generations of nanomachines with ultimate applications in bioanalysis and clinical diagnoses.
Topics & Concepts
JanusmicroRNADual (grammatical number)FluorescenceDNACancer cellCancer detectionCancerCancer imagingComputational biologyBiophysicsChemistryNanotechnologyMaterials scienceBiologyBiochemistryPhysicsGeneGeneticsOpticsLiteratureArtAdvanced biosensing and bioanalysis techniquesNanopore and Nanochannel Transport StudiesGold and Silver Nanoparticles Synthesis and Applications