PTPMT1 protects cardiomyocytes from necroptosis induced by γ-ray irradiation through alleviating mitochondria injury
Jing Yi, Liang Yue, Yuning Zhang, Tao Ning, Han Duan, Lin Lv, Ying‐Xia Tan, Hua Wang
Abstract
Effective strategies are still lacking for treating RIHD, with unclear pathological mechanisms. In cardiomyocytes model of radiation-induced injuries, we found γ-ray irradiation decreased the expression of PTPMT1, increased oxidative stress, and induced mitochondrial dysfunction and necroptosis in iPSC-CMs. ROS inhibition attenuated radiation-induced mitochondrial damage and necroptosis. PTPMT1 protected cardiomyocytes from necroptosis induced by γ-ray irradiation by alleviating mitochondrial injury. Therefore, PTPMT1 might be a potential strategy for treating RIHD.
Topics & Concepts
NecroptosisMitochondrionIrradiationCell biologyChemistryProgrammed cell deathBiologyApoptosisPhysicsBiochemistryNuclear physicsMitochondrial Function and PathologyCell death mechanisms and regulationAutophagy in Disease and Therapy