Immune Imprinting in the Influenza Ferret Model
Amanda L. Skarlupka, Ted M. Ross
Abstract
The initial exposure to influenza virus usually occurs during childhood. This imprinting has long-lasting effects on the immune responses to subsequent infections and vaccinations. Animal models that are used to investigate influenza pathogenesis and vaccination do recapitulate the pre-immune history in the human population. The establishment of influenza pre-immune ferret models is necessary for understanding infection and transmission and for designing efficacious vaccines.
Topics & Concepts
Imprinting (psychology)Immune systemVaccinationImmunologyVirologyBiologyVirusPopulationInfluenza vaccineMedicineGeneticsGeneEnvironmental healthInfluenza Virus Research StudiesRespiratory viral infections researchNeuroscience of respiration and sleep