Biotransformation Changes Bioaccumulation and Toxicity of Diclofenac in Aquatic Organisms
Qiuguo Fu, Davide Fedrizzi, Verena Kosfeld, Christian Schlechtriem, Vera Ganz, Samuel Derrer, Daniel Rentsch, Juliane Hollender
Abstract
-adenosylmethionine-dependent carboxylic acid methyltransferase. Methylation of diclofenac was further detected in fish hepatocytes and human urine, indicating a broader relevance. Therefore, potentially methylated metabolites of polar contaminants should be considered for a comprehensive risk assessment in the future.
Topics & Concepts
BioaccumulationBiotransformationDiclofenacToxicityEnvironmental chemistryAquatic environmentChemistryBiologyEcologyOrganic chemistryBiochemistryEnzymePharmaceutical and Antibiotic Environmental ImpactsAnalytical chemistry methods developmentChemistry and Chemical Engineering