Large-leaf yellow tea attenuates high glucose-induced vascular endothelial cell injury by up-regulating autophagy and down-regulating oxidative stress
Pu Wang, Yihai Huang, Jiayue Ren, Yuezhao Rong, Lili Fan, Peng Zhang, Xueying Zhang, Junxiao Xi, Shuying Mao, Su Min, Baobao Zhang, Guan‐Hu Bao, Feihua Wu
Abstract
HLYTBE protects HUVECs against HG-induced injury via AMPK/mTOR-regulated autophagy and inhibiting oxidative stress. Moreover, HLYTBE improves glucose and lipid metabolism, exhibits antioxidant activity and reduces arterial vascular injury in vivo .
Topics & Concepts
AutophagyAMPKGlutathione peroxidaseOxidative stressGlutathioneChemistryReactive oxygen speciesPharmacologySuperoxide dismutaseInternal medicineEndocrinologyBiochemistryProtein kinase AApoptosisBiologyMedicineKinaseEnzymeAutophagy in Disease and TherapyTea Polyphenols and EffectsAdvanced Glycation End Products research