Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions
Mengchen Lu, Hong-Li Shao, Tian Liu, Qidong You, Zhengyu Jiang
Topics & Concepts
KEAP1ChemistryTranscription factorIn vivoSulfonamidePhenylacetic acidInflammationOxidative stressBiochemistryPharmacologyGeneStereochemistryBiologyImmunologyGeneticsGenomics, phytochemicals, and oxidative stressNitrogen and Sulfur Effects on BrassicaMacrophage Migration Inhibitory Factor