Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress
Carly M. Darden, Srividya Vasu, Jordan Mattke, Liu Yang, Christopher J. Rhodes, Bashoo Naziruddin, Michael C. Lawrence
Abstract
/CN/NFATc2 signaling. They further demonstrate the utility of targeting CN/NFATc2 to restore β-cell function.
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BCalcineurinCell biologyDownregulation and upregulationTranscription factorChemistrymTORC1BiologySignal transductionEndocrinologyInternal medicineBiochemistryGeneMedicineTransplantationPancreatic function and diabetesSignaling Pathways in DiseaseDiabetes and associated disorders