Corallopyronin A: antimicrobial discovery to preclinical development
Anna K. Krome, Tim Becker, Stefan Kehraus, Andrea Schiefer, Michael Gütschow, Lillibeth Chaverra-Muñoz, Stephan Hüttel, Rolf Jansen, Marc Stadler, Alexandra Ehrens, Domen Pogorevc, Rolf Müller, Marc P. Hübner, Thomas Hesterkamp, Kenneth Pfarr, Achim Hoerauf, Karl Wagner, Gabriele M. König
Abstract
Identifying new antibiotics and their further development is a priority of natural product research. The antibiotic corallopyronin A serves in this review as a show case for the development of a naturally occurring antibiotic compound.
Topics & Concepts
AntimicrobialComputational biologyDrug discoveryBiologyMicrobiologyBioinformaticsInsect Utilization and EffectsPhytochemistry and Bioactivity StudiesMedicinal Plants and Neuroprotection