Development of [<sup>18</sup>F]AmBF<sub>3</sub> Tetrazine for Radiolabeling of Peptides: Preclinical Evaluation and PET Imaging of [<sup>18</sup>F]AmBF<sub>3</sub>-PEG<sub>7</sub>-Tyr<sup>3</sup>-Octreotide in an AR42J Pancreatic Carcinoma Model
Sofia Otaru, Andreas Paulus, Surachet Imlimthan, Iida Kuurne, Helena E. Virtanen, Heidi Liljenbäck, Tuula Tolvanen, Tatsiana Auchynnikava, Anne Roivainen, K. Helariutta, Mirkka Sarparanta, Anu J. Airaksinen
Abstract
-Tz demonstrated that it offers potential as a prosthetic group for rapid radiolabeling of biomolecules in mild conditions using bioorthogonal chemistry.
Topics & Concepts
BiodistributionChemistryIn vivoEx vivoPositron emission tomographyRadiochemistryPreclinical imagingNuclear medicineTetrazineIn vitroBiochemistryBiologyBiotechnologyMedicineOrganic chemistryRadiopharmaceutical Chemistry and ApplicationsHER2/EGFR in Cancer ResearchPeptidase Inhibition and Analysis