Electrochemical‐Induced C(sp<sup>3</sup>)−H Dehydrogenative Trimerization of Pyrazolones to Tripyrazolones
Jing Ma, Jianjing Yang, Kelu Yan, Xue Sun, Wei Wei, Laijin Tian, Jiangwei Wen
Abstract
Abstract The electrochemical‐induced three‐component C(sp 3 )−H dehydrogenative trimerization of pyrazolones to tripyrazolones with hydrogen evolution has been accomplished under the metal‐ and external‐oxidant‐free conditions. This protocol provides an efficient and eco‐friendly method for the synthesis of tripyrazolones, which avoids the use of metals and stoichiometric chemical oxidants. A wide range of functional groups was tolerated to give selectively the desired products in high yields. Importantly, such an electrochemical‐oxidation‐induced dehydrogenative trimerization reaction could be easily scaled up with excellent efficiency.
Topics & Concepts
PyrazolonesChemistryElectrochemistryStoichiometryCombinatorial chemistryMetalOrganic chemistryElectrodePhysical chemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques