O-GlcNAcylation: A major nutrient/stress sensor that regulates cellular physiology
Lance Wells, Gerald W. Hart
Abstract
O-GlcNAcylation of nuclear, cytoplasmic, and mitochondrial proteins was discovered over four decades ago (1,2). Work from many laboratories has shown that the cycling of O-linked N-acetylglucosamine (O-GlcNAc) on proteins serves as an essential nutrient/stress sensor to regulate transcription, signaling, DNA methylation and repair, translation, protein trafficking, and cell division in response to glucose and other nutrients (for review, (3)). Global O-GlcNAcylation is also increased in most forms of cellular stress (4).
Topics & Concepts
NutrientStress (linguistics)Cell physiologyCell biologyChemistryBiologyPhysiologyBiochemistryEcologyCellPhilosophyLinguisticsGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and SynthesisGalectins and Cancer Biology