Rhodium(<scp>iii</scp>)-catalyzed <i>ortho</i>-C–H amidation of 2-arylindazoles with a dioxazolone as an amidating reagent
Payel Ghosh, Sadhanendu Samanta, Alakananda Hajra
Abstract
A simple and efficient method for the directed amidation of a wide range of 2-arylindazoles has been established for the first time through a rhodium-catalyzed C-H activation reaction with alkyl, aryl and heteroaryl dioxazolones. A series of N-(2-(2H-indazol-2-yl)phenyl)acetamide derivatives were synthesized in excellent yields. A mechanistic study was conducted to describe C-H bond cleavage which is likely to be involved in the rate determining step.
Topics & Concepts
ChemistryRhodiumReagentArylCatalysisAlkylCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques