Inhibitory effects of Atlantic cod (<i>Gadus morhua</i>) peptides on RANKL-induced osteoclastogenesis <i>in vitro</i> and osteoporosis in ovariectomized mice
Meilian Yang, Di Wu, Shuzhen Cheng, Yu Dong, Chao Wu, Zhenyu Wang, Ming Du
Abstract
, GMP protects mice against ovariectomy-induced bone loss by regulating the balance of major factors released in bone formation and resorption. Taken together, GMP could be a potential candidate or dietary supplement for the prevention of osteoporosis.
Topics & Concepts
GadusOsteoclastOvariectomized ratRANKLBone resorptionBone mineralEndocrinologyOsteoporosisInternal medicineChemistryActivator (genetics)In vivoBone remodelingResorptionIn vitroCell biologyReceptorBiologyBiochemistryMedicineBiotechnologyEstrogenFisheryFish <Actinopterygii>Bone Metabolism and DiseasesBone and Dental Protein StudiesBone health and treatments