De Novo Construction of Substituted Terephthalates via Phosphine Catalyzed Domino Benzannulation Reactions
Dan Wang, Junhui Lin, Yannan Zhu, You Huang
Abstract
Abstract The robustness of phosphine catalysis enabling the domino benzannulation reactions of allenoates with enamines is described. A broad array of substituted terephthalates were delivered under simple and practical reaction conditions. Furthermore, the reaction could be carried out on a gram scale with higher yield, and various conversions of the terephthalate products demonstrate the versatility of this transformation. magnified image
Topics & Concepts
DominoChemistryPhosphineCatalysisYield (engineering)Cascade reactionCombinatorial chemistryReaction conditionsOrganic chemistryMaterials scienceMetallurgyAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisSynthetic Organic Chemistry Methods