Mesenchymal stem cells for enhancing biological healing after meniscal injuries
Hye Chang Rhim, Ok Hee Jeon, Seung-Beom Han, Ji‐Hoon Bae, Dong Won Suh, Ki-Mo Jang
Abstract
. Thus far, the application of MSCs, including bone marrow-derived, synovium-derived, and adipose-derived MSCs, has shown promising results in preclinical studies in different animal models. These preclinical studies could be categorized into intra-articular injection and tissue-engineered construct application according to delivery method. Despite promising results in preclinical studies, there is still a lack of clinical evidence. This review describes the basic knowledge, current treatment, and recent studies regarding the application of MSCs in treating meniscal injuries. Future directions for MSC-based approaches to enhance meniscal healing are suggested.