Synthesis of indole inhibitors of silent information regulator 1 (SIRT1), and their evaluation as cytotoxic agents
Hanna Laaroussi, Ying Ding, Yuou Teng, Patrick Deschamps, Michel Vidal, Peng Yu, Sylvain Broussy
Topics & Concepts
ChemistrySubstituentSIRT2SirtuinIndole testStereochemistryRegulatorSirtuin 1Cytotoxic T cellEnzymeBiochemistryIn vitroNAD+ kinaseDownregulation and upregulationGeneSirtuins and Resveratrol in MedicineBioactive natural compoundsTea Polyphenols and Effects