Antigen identification for HLA class I– and HLA class II–restricted T cell receptors using cytokine-capturing antigen-presenting cells
Mark N. Lee, Matthew Meyerson
Abstract
T cells and allows pooled screening of thousands of encoded peptides to enable epitope discovery for orphan TCRs. Our technology may enable identification of HLA-epitope-TCR complexes relevant to disease control, etiology, or treatment.
Topics & Concepts
ImmunologyHuman leukocyte antigenAntigenEpitopeCD8CytokineBiologyAntigen-presenting cellImmune systemT cellCAR-T cell therapy researchT-cell and B-cell ImmunologyImmunotherapy and Immune Responses