Cardiovascular manifestations in Marfan syndrome.
Cecilia Lazea, Simona Bucerzan, Mirela Crișan, Camelia Alkhzouz, Diana Miclea, Crina Şufană, Gabriel Cismaru, Paula Grigorescu‐Sido
Abstract
Marfan syndrome (MFS) is an autosomal dominant inherited disease of the connective tissue with multiorgan involvement (skeleton, cardiovascular, eyes, skin, lungs). Cardiovascular involvement is variable and represents the major cause of morbidity and mortality in Marfan syndrome. We provide a comprehensive description of cardiovascular manifestations in Marfan syndrome, genotype-phenotype correlations and assessment of cardiovascular abnormalities and complications.
Topics & Concepts
Marfan syndromeMedicineDiseaseConnective tissue diseaseConnective tissueCardiologyInternal medicinePathologyAutoimmune diseaseConnective tissue disorders researchAortic Disease and Treatment ApproachesCardiovascular Issues in Pregnancy