Experimentally designed chromatographic method for the simultaneous analysis of dimenhydrinate, cinnarizine and their toxic impurities
Fadwa H. Edrees, Ahmed S. Saad, Mohammed T. Alsaadi, Noha H. Amin, Nada S. Abdelwahab
Abstract
for DMH, CIN, BZP and DPP, respectively. By application of the proposed method to the market dosage form, no interference from excipients was observed. Moreover, the greenness of the method was evaluated using the National Environmental Method Index (NEMI), Analytical Eco-Scale and Green Analytical Procedure Index (GAPI) metrics and the results revealed the green environmental impact of the developed method.
Topics & Concepts
CinnarizineChromatographyChemistryImpurityRetention timeHigh-performance liquid chromatographyPharmacologyOrganic chemistryMedicineAnalytical Chemistry and ChromatographyCancer therapeutics and mechanismsAnalytical Methods in Pharmaceuticals