Circulating microbiome in patients with portal hypertension
Rolandas Gedgaudas, Jasmohan S. Bajaj, Jurgita Skiecevičienė, Greta Varkalaitė, Gabija Jurkeviciute, Sigita Gelman, Irena Valantienė, Romanas Zykus, Andrius Pranculis, Corinna Bang, André Franke, Christoph Schramm, Juozas Kupčinskas
Abstract
abundance was correlated with IL-8 levels in the hepatic vein. In conclusion, we demonstrated a distinct circulating blood microbiome profile in patients with cirrhosis, showing that specific bacterial genera in blood are marginally associated with SPH, Model for End-Stage Liver Disease score, and inflammation biomarkers; however, circulating microbial composition failed to predict PH severity.
Topics & Concepts
CirrhosisBiologyMicrobiomePrevotellaMicrobiologyBacteroides fragilisDysbiosisGut floraBacteroidesImmunologyInternal medicineBacteriaMedicineBioinformaticsAntibioticsGeneticsLiver Disease and TransplantationLiver Disease Diagnosis and TreatmentGut microbiota and health