Tartrate-Resistant Acid Phosphatase 5/ACP5 Interacts with p53 to Control the Expression of SMAD3 in Lung Adenocarcinoma
Yinan Hu, Jun Yu, Qi Wang, Lei Zhang, Xueying Chen, Yong Cao, Jianping Zhao, Yongjian Xu, Dingsheng Jiang, Yi Wang, Weining Xiong
Abstract
, which promotes EMT in lung adenocarcinoma cells. In summary, the present study provides a theoretical basis and important scientific evidence on the key role of ACP5 in lung adenocarcinoma progression by inducing EMT via the regulation of p53/SMAD3 signaling.
Topics & Concepts
AdenocarcinomaLungCancer researchCarcinogenesisCell growthInternal medicineEpithelial–mesenchymal transitionApoptosisChemistryMetastasisBiologyMedicineCancerBiochemistryMicroRNA in disease regulationBone Metabolism and DiseasesRNA modifications and cancer