Interaction of saffron and its constituents with Nrf2 signaling pathway: A review.
Arian Khoshandam, Bibi Marjan Razavi, Hossein Hosseinzadeh
Abstract
", crocetin, crocin, safranal, picrocrocin, "nuclear factor erythroid 2-related factor 2", and Nrf2. Saffron and its constituents could have protective properties through various mechanisms particularly the Nrf2/HO-1/Keap1 signaling pathway in different tissues such as the liver, heart, brain, pancreas, lung, joints, colon, etc. The vast majority of studies discussed in this review indicate that saffron and its constituents could induce the Nrf2 signaling pathway leading to its anti-oxidant and therapeutic effects.
Topics & Concepts
SafranalCrocinCrocetinCrocus sativusSignal transductionPharmacologyTraditional medicineChemistryMedicineBiochemistrySaffron Plant Research StudiesMedicinal Plants and Bioactive CompoundsPhytochemical and Pharmacological Studies