Super-Enhancer LncRNA LINC00162 Promotes Progression of Bladder Cancer
Xin Wang, Ruirui Zhang, Shuilian Wu, Liping Shen, Meixia Ke, Yan Ouyang, Mengqi Lin, Yiting Lyu, Binuo Sun, Zhijian Zheng, Jialei Yang, Jie Yang, Wen‐Min Lu, Yiping Yang, Danni Li, Yunfeng Zou, Haishan Huang, Aruo Nan
Abstract
, while knocking down the expression of PTTG1IP could restore the proliferative activity of bladder cancer cells. In addition, both LINC00162 and PTTG1IP were found to be able to bind to THRAP3, a transcription-related protein. And THRAP3 can regulate PTTG1IP expression. Finally, we demonstrated a mechanism that LINC00162 could regulate PTTG1IP expression through binding THRAP3. This study provided a potential target molecule for clinical treatment of bladder cancer.
Topics & Concepts
Bladder cancerEnhancerCancer researchCancerLong non-coding RNATranscription (linguistics)In vivoCancer cellRNATranscription factorBiologyMedicineGeneGeneticsPhilosophyLinguisticsCancer-related molecular mechanisms researchNuts composition and effectsNatural product bioactivities and synthesis