Matrisomal components involved in regenerative wound healing in axolotl and <i>Acomys</i>: implications for biomaterial development
Nancy Avila-Martinez, Merel Gansevoort, Juul Verbakel, Haarshaadri Jayaprakash, Inês M. Araújo, Marta Vitorino, Gustavo Tiscórnia, Toin H. Van Kuppevelt, Willeke F. Daamen
Abstract
and axolotl were selected. Matrisome and GAG related genes were extracted from each dataset and the resulting lists of genes were compared. In our analysis, we found several genes that were consistently upregulated, suggesting possible involvement in regenerative processes. Most of the components have been implicated in regulation of cell behavior, extracellular matrix remodeling and wound healing. Incorporation of such pro-regenerative factors into biomaterials may help to shift pro-fibrotic processes to regenerative responses in treated wounds.
Topics & Concepts
AxolotlBiomaterialWound healingRegeneration (biology)BiologyCell biologyEngineeringBiomedical engineeringImmunologyElectrospun Nanofibers in Biomedical ApplicationsWound Healing and TreatmentsSilk-based biomaterials and applications