Psathyrins: Antibacterial Diterpenoids from <i>Psathyrella candolleana</i>
Ya-Pei Liu, Quan Dai, Wen‐Xuan Wang, Juan He, Zheng-Hui Li, Tao Feng, Ji‐Kai Liu
Abstract
Two skeletally novel tetracyclic diterpenoids, psathyrins A (1) and B (2), have been characterized from cultures of the basidiomycete Psathyrella candolleana. Their structures including absolute configurations were established by means of spectroscopic methods, as well as ECD calculations. They possess a novel 5/5/4/6-fuesd ring system, for which the biosynthetic pathway is proposed. Compounds 1 and 2 inhibited the growth of Staphylococcus aureus and Salmonella enterica.
Topics & Concepts
Staphylococcus aureusSalmonella entericaStereochemistryAntibacterial activityChemistryRing (chemistry)TerpenoidAbsolute configurationBiologyMicrobiologyBacteriaBiochemistryEscherichia coliOrganic chemistryGeneGeneticsPlant biochemistry and biosynthesisMicrobial Natural Products and BiosynthesisNatural product bioactivities and synthesis