Targeting Fibroblast Activation Protein: Radiosynthesis and Preclinical Evaluation of an <sup>18</sup>F-Labeled FAP Inhibitor
Johannes Toms, Jürgen Kogler, Simone Maschauer, Christoph Daniel, Christian Schmidkonz, Torsten Kuwert, Olaf Prante
Abstract
Fibroblast activation protein (FAP) has emerged as an interesting molecular target used in the imaging and therapy of various types of cancers. 68 Ga-labeled chelator-linked FAP inhibitors (FAPIs) have been successfully applied to PET imaging of various tumor types.
Topics & Concepts
RadiosynthesisFibroblast activation protein, alphaBiodistributionChemistryIn vitroRadiochemistryInternalizationIn vivoMolecular biologyBiochemistryCellMedicineCancerBiologyBiotechnologyInternal medicinePeptidase Inhibition and AnalysisCardiac Structural Anomalies and RepairProtease and Inhibitor Mechanisms