Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
Juan M. Schvartzman, Grace Forsyth, Henry Walch, Walid K. Chatila, Angelo Taglialatela, Brian J. Lee, Xiaolu Zhu, Steven Gershik, Francesco V. Cimino, Anthony Santella, Kamal Menghrajani, Alberto Ciccia, Richard P. Koche, Francisco Sánchez-Vega, Shan Zha, Craig B. Thompson
Topics & Concepts
BiologyHomologous recombinationHeterochromatinDNA repairReplication protein ADNA replicationChromatinMutantMolecular biologyMutationPoly ADP ribose polymeraseGeneticsDNAPolymeraseGeneDNA-binding proteinTranscription factorDNA Repair MechanismsPARP inhibition in cancer therapyCancer therapeutics and mechanisms