Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration
Yini Li, Xiaoyang Dou, Jun Liu, Yu Xiao, Zhe Zhang, Lindsey R. Hayes, Rong Wu, Xiujuan Fu, Yingzhi Ye, Bing Yang, Lyle W. Ostrow, Chuan He, Shuying Sun
Topics & Concepts
C9orf72Trinucleotide repeat expansionNeurodegenerationBiologyN6-MethyladenosineRNAAmyotrophic lateral sclerosisFrontotemporal dementiaCell biologyInduced pluripotent stem cellTranscriptomeMessenger RNAGene expressionGeneGeneticsMethylationMedicineMethyltransferaseInternal medicineDementiaDiseaseEmbryonic stem cellAlleleRNA modifications and cancerRNA Research and SplicingCancer-related gene regulation