Luciferase- and HaloTag-based reporter assays to measure small-molecule-induced degradation pathway in living cells
Martin P. Schwalm, Krishna Saxena, Susanne Müller, Stefan Knapp
Topics & Concepts
Small moleculeComputational biologyCRISPRHEK 293 cellsHigh-throughput screeningSynthetic biologyProteomicsCell biologyProtein degradationTernary complexCell cultureBiologyChemistryMolecular biologyBiochemistryGeneticsGeneEnzymeProtein Degradation and InhibitorsCAR-T cell therapy researchUbiquitin and proteasome pathways