Synthesis of Novel 2,3-Dihydro-1,5-Benzothiazepines as α-Glucosidase Inhibitors: <i>In Vitro</i>, <i>In Vivo</i>, Kinetic, SAR, Molecular Docking, and QSAR Studies
Rabia Mehmood, Ehsan Ullah Mughal, Eslam B. Elkaeed, Rami J. Obaid, Yasir Nazir, Hanan Al-Ghulikah, Nafeesa Naeem, Munirah M. Al‐Rooqi, Saleh A. Ahmed, Syed Wadood Ali Shah, Amina Sadiq
Abstract
structures and selected properties. There is a correlation between the experimental and theoretical results. Thus, these novel compounds could serve as potential candidates to become leads for the development of new drugs provoking an anti-hyperglycemic effect.
Topics & Concepts
AcarboseIn vivoChemistryQuantitative structure–activity relationshipDocking (animal)IC50In vitroStereochemistryProtein Data Bank (RCSB PDB)EnzymeBiochemistryPharmacologyCombinatorial chemistryBiologyMedicineBiotechnologyNursingNatural Antidiabetic Agents StudiesSynthesis and biological activityCholinesterase and Neurodegenerative Diseases