Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo
Zhiqiang Li, Xinzhi Li, Mingbo Su, Lixin Gao, Yubo Zhou, Bingchuan Yuan, Xilin Lyu, Ziqin Yan, Chujiao Hu, Hao Zhang, Cheng Luo, Zheng Chen, Jia Li, Yujun Zhao
Abstract
also decreased immune cell infiltration into the injured liver tissue. Overall, these studies provide examples that an NIK inhibitor is able to suppress toxin-induced liver inflammations, which indicates its therapeutic potentials for the treatment of liver inflammatory diseases.
Topics & Concepts
In vivoPharmacologyIn vitroInflammationChemistryDownregulation and upregulationKinaseImmune systemLiver injuryIC50ImmunologyBiochemistryMedicineBiologyGeneBiotechnologyNF-κB Signaling PathwaysCell death mechanisms and regulationinterferon and immune responses