Guidelines for the diagnosis and treatment of neurally mediated syncope in children and adolescents (revised 2024)
Cheng Wang, Ying Liao, Shuo Wang, Hong Tian, Min Huang, Xiangyu Dong, Lin Shi, Yaqi Li, Jing-Hui Sun, Junbao Du, Hongfang Jin, Jin-Dou An, Xinjiang An, Jie Chen, Li‐Qing Chen, Mingwu Chen, Shuqin Chen, Qi Chen, Yonghong Chen, Sun Chen, Chen Zhi, Adolphus Kai-tung Chau, Maoping Chu, Hui-Ying Cui, Xiangyu Dong, Junbao Du, Shuxu Du, Zhong‐Dong Du, Hongyu Duan, Junkai Duan, Lin Feng, Lijun Fu, Fang Gao, Lu Gao, Wei Gao, Fangqi Gong, Li Gu, Hong Gu, Yonghao Gui, Zhenhui Han, Bo Han, Ling Han, Bing He, Xue-Hua He, Zhixu He, Xiufen Hu, Y.D. Hu, Yimin Hua, Guoying Huang, Hui-Tao Huang, Min Huang, Ping Huang, Xing‐Yuan Huang, Yujuan Huang, Shou-Yuan Jiang, Hongfang Jin, Mei Jin, Yan-Zhe Lei, Bo Li, Fen Li, Li Li, Tao Li, Xiaoming Li, Xiaohui Li, Yan Li, Yun Li, Zipu Li, Yongmei Liang, Ying Liao, Fang Liu, Wei Liu, Xiaoyan Liu, Yali Liu, Huiling Lü, Haitao Lv, Tiewei Lv, Lu-Yi Ma, Bao-Quan Pan, Xiangbin Pan, Silin Pan, Yusheng Pang, Hua Peng, Jinhua Piao, Mingyang Qian, Wei Qian, Yuming Qin, Jie Shen, Lin Shi, Guodong Song, Jing-Hui Sun, Hong Tian, Jie Tian, Cheng Wang, Cui-Ling Wang, Hong Wang, Lei Wang, Lihong Wang, Lin Wang, Qin Wang, Shushui Wang
Abstract
BACKGROUND: Significant progress has been made in the diagnosis and treatment of pediatric syncope since the publication of the "2018 Chinese Pediatric Cardiology Society (CPCS) guideline for diagnosis and treatment of syncope in children and adolescents" ("2018 Edition Guidelines"). Therefore, we have revised and updated it to assist pediatricians in effectively managing children with syncope. DATA SOURCES: According to the "2018 Edition Guidelines", the expert groups collected clinical evidence, evaluated preliminary recommendations, and then organized open-ended discussions to form the recommendations. This guideline was developed by reviewing the literature and studies in databases including PubMed, Cochrane, EMBASE, China Biomedical Database, and Chinese Journal Full-text Database up to April 2024. Search terms included "syncope", "children", "adolescents", "diagnosis", and "treatment." RESULTS: The guidelines were based on the latest global research progress and were evidence-based. The classification of syncope etiology, diagnostic procedures, postural tests, such as the active standing test, head-up tilt test, and active sitting test, clinical diagnosis, and individualized treatment for neurally mediated syncope in pediatric population were included. CONCLUSIONS: The guidelines were updated based on the latest literature. The concepts of sitting tachycardia syndrome and sitting hypertension were introduced and the comorbidities of neurally mediated syncope were emphasized. Some biomarkers used for individualized treatment were underlined. Specific suggestions were put forward for non-pharmacological therapies as well as the follow-up process. The new guidelines will provide comprehensive guidance and reference for the diagnosis and treatment of neurally mediated syncope in children and adolescents.