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PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma

Xiaosai Yao, Jing Han Hong, Amrita M. Nargund, Michelle Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You Fu Pan, Yan Shan Ong, Kiat Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Ming‐Hui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, P. Andrew Futreal, Jing Tan, Joe Yeong, Wanjin Hong, Robert L. Yauch, Kenneth Tou En Chang, Radoslaw M. Sobota, Patrick Tan, Bin Tean Teh

2023Nature Cell Biology24 citationsDOI

Topics & Concepts

Renal cell carcinomaCellCell biologyBiologyCancer researchClear cell renal cell carcinomaGeneticsMedicinePathologyRenal cell carcinoma treatmentCancer Mechanisms and TherapyChromatin Remodeling and Cancer
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma | Litcius