<i>Chi3l1</i> /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis
Brian V. Lananna, Celia A. McKee, Melvin W. King, Jorge L. Del‐Aguila, Julie Dimitry, Fabiana Farias, Collin J. Nadarajah, David D. Xiong, Chun Guo, Alexander J. Cammack, Jack A. Elias, Jinsong Zhang, Carlos Cruchaga, Erik S. Musiek
Abstract
Chi3l1 /YKL-40 is regulated by BMAL1 in astrocytes and influences AD pathogenesis in both mouse models and humans.
Topics & Concepts
AstrocyteNeuroinflammationBiologyMicrogliaCell biologyPathogenesisCLOCKCircadian clockCircadian rhythmImmunologyEndocrinologyInflammationCentral nervous systemCircadian rhythm and melatoninAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms