Design, synthesis and evaluation of novel indole-2-carboxamides for growth inhibition of <i>Mycobacterium tuberculosis</i> and paediatric brain tumour cells
Shahinda S. R. Alsayed, Shichun Lun, Anders W. Bailey, Amreena Suri, Chiang‐Ching Huang, Mauro Mocerino, Alan D. Payne, Simone Treiger Sredni, William R. Bishai, Hendra Gunosewoyo
Abstract
(viability) = 119 μM]. This suggests that an indoleamide scaffold can be fine-tuned to confer a set of derivatives with selective antitubercular and/or antitumour activities.
Topics & Concepts
Indole testMycobacterium tuberculosisTuberculosisChemistryMicrobiologyCombinatorial chemistryPharmacologyStereochemistryMedicineBiologyPathologyCancer therapeutics and mechanismsTuberculosis Research and EpidemiologyPhenothiazines and Benzothiazines Synthesis and Activities