Evidence of impaired functional sympatholysis in patients with heart failure with preserved ejection fraction
Jeremy K. Alpenglow, Kanokwan Bunsawat, Michael A. Francisco, Jesse C. Craig, Jarred Iacovelli, John Ryan, D. Walter Wray
Abstract
Data from the current study suggest that functional sympatholysis, or the ability to adequately attenuate sympathetic nervous system (SNS)-mediated vasoconstriction during exercise, is impaired in patients with heart failure with preserved ejection fraction (HFpEF). These observations extend the current understanding of HFpEF pathophysiology by implicating inadequate functional sympatholysis as an important contributor to reduced exercising muscle blood flow in this patient group.
Topics & Concepts
MedicineCardiologyInternal medicineHeart failure with preserved ejection fractionVasoconstrictionHeart failureForearmBlood pressureEjection fractionSurgeryHeart Rate Variability and Autonomic ControlCardiovascular and exercise physiologyCardiac Health and Mental Health