Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis
Jiawei Wu, Zhonghong Wei, Peng Cheng, Cheng Qian, Fangming Xu, Yang Yu, Aiyun Wang, Wenxing Chen, Zhiguang Sun, Yin Lu
Abstract
We showed that rhein could modulate gut microbiota, which indirectly changed purine metabolism in the intestine and subsequently alleviated colitis. Our study has identified a new approach to the clinical treatment of colitis.
Topics & Concepts
ColitisGut floraMesenteric lymph nodesInflammatory bowel diseaseUric acidUlcerative colitisProbioticBiologyImmunologyPharmacologyInternal medicineMedicineImmune systemBacteriaDiseaseGeneticsGut microbiota and healthGinseng Biological Effects and ApplicationsTryptophan and brain disorders