The Complexity of the cGAS-STING Pathway in CNS Pathologies
Amelia L. Fryer, Amar Daud Iskandar Abdullah, Juliet M. Taylor, Peter J. Crack
Abstract
Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate the progression of many CNS pathologies both acute and chronic. The role of adaptor protein Stimulator of Interferon Genes (STING) is increasingly appreciated to instigate type-I IFN-mediated neuroinflammation. As an upstream regulator of type-I IFNs, STING modulation presents a novel therapeutic opportunity to mediate inflammation in the CNS. This review will detail the current knowledge of protective and detrimental STING activity in acute and chronic CNS pathologies and the current therapeutic avenues being explored.
Topics & Concepts
StingNeuroinflammationRegulatorSignal transducing adaptor proteinInflammationMedicineNeuroscienceImmunologyStimulator of interferon genesBiologySignal transductionImmune systemInnate immune systemGeneCell biologyBiochemistryAerospace engineeringEngineeringinterferon and immune responsesViral Infections and VectorsInflammasome and immune disorders