Effect of Magnesium Oxide on the Stability of ACE Inhibitors in Simple Suspension Method
Yoshihiro Takano, Haruka Kabe, Kenta Mizoi, Keiko Hakoda, Tomoko Mineno, Kentarô Yano, Takuo Ogihara
2021Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)27 citationsDOIOpen Access PDF
Abstract
In the simple suspension method, the intended medicine is suspended in hot water when administered to a patient by tube. Suspension of the laxative, magnesium oxide is reported to hydrolyze ester-type drugs. Because several angiotensin converting enzyme (ACE) inhibitors have ester bonds in their structure, magnesium oxide may cause incompatibility when suspended with an ACE inhibitor. The purpose of this study was to clarify the effect of magnesium oxide on the stability of eight kinds of ACE inhibitors in the simple suspension method.
Topics & Concepts
MagnesiumHydrolysisSuspension (topology)ChemistryLaxativeOxideChromatographyPharmacologyOrganic chemistryMedicineSurgeryMathematicsHomotopyPure mathematicsConstipationPharmacy and Medical PracticesSafe Handling of Antineoplastic Drugs