Synthesis of ester-functionalized indolo[2,1-<i>a</i>]isoquinolines<i>via</i>iron-catalyzed radical cascade cyclization of 2-aryl-<i>N</i>-acryloyl indoles with carbazates
Yucai Tang, Kaiming Dai, Xingxian Xiang, Yiting Yang, Min Li
Abstract
]isoquinoline derivatives has been developed. The reaction features mild reaction conditions and broad functional group tolerance. Moreover, the ester group could be easily converted to the corresponding free acid and alcohol, and has high potential applications in organic and pharmaceutical synthesis. A radical pathway was proposed to explain this experiment.
Topics & Concepts
ChemistryCascadeArylCatalysisRadical cyclizationCombinatorial chemistryMedicinal chemistryOrganic chemistryAlkylChromatographyCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsRadical Photochemical Reactions