Roles of calcitonin gene-related peptide in the skin, and other physiological and pathophysiological functions
Yee Jung Kim, Richard D. Granstein
Abstract
Skin immunity is regulated by many mediator molecules. One is the neuropeptide calcitonin gene-related peptide (CGRP). CGRP has roles in regulating the function of components of the immune system including T cells, B cells, dendritic cells (DCs), endothelial cells (ECs), and mast cells (MCs). Herein we discuss actions of CGRP in mediating inflammatory and vascular effects in various cutaneous models and disorders.
Topics & Concepts
Calcitonin gene-related peptideNeuropeptideCalcitoninImmune systemMediatorCell biologyInflammationFunction (biology)BiologyPeptideImmunityImmunologyReceptorEndocrinologyBiochemistryNeuropeptides and Animal PhysiologyDermatology and Skin DiseasesUrticaria and Related Conditions