The dilemma of selecting a first line CDK4/6 inhibitor for hormone receptor-positive/HER2-negative metastatic breast cancer
Albert Grinshpun, Sara M. Tolaney, Harold J. Burstein, Rinath Jeselsohn, Erica L. Mayer
Abstract
The combination of an endocrine agent with a CDK4/6 inhibitor is the standard of care in the first-line setting for patients with hormone receptor-positive, HER2-negative metastatic breast cancer. Randomized trials have demonstrated similar and significant improvements in progression-free survival using the three available CDK4/6 inhibitors and led to regulatory approval. However, mature overall survival data now suggest potential differences among the various agents, suggesting an evolution in selection preferences.
Topics & Concepts
Metastatic breast cancerHER2 negativeOncologyInternal medicineHormone receptorBreast cancerMedicineCancerHormoneAdvanced Breast Cancer TherapiesBreast Cancer Treatment StudiesHER2/EGFR in Cancer Research