Astrocyte-specific activation of sigma-1 receptors in mPFC mediates the faster onset antidepressant effect by inhibiting NF-κB-induced neuroinflammation
Jingya Wang, Peng Ren, Lin-Yu Cui, Jing-Yao Duan, Honglei Chen, Zhirui Zeng, Yunfeng Li
Topics & Concepts
NeuroinflammationAntidepressantReceptorAgonistAstrocyteMicrogliaGene knockdownPrefrontal cortexPharmacologyNeuroscienceChemistryPsychologyMedicineInternal medicineInflammationCentral nervous systemHippocampusApoptosisCognitionBiochemistryTryptophan and brain disordersPharmacological Receptor Mechanisms and EffectsNeuroinflammation and Neurodegeneration Mechanisms