Efficient Synthesis of α‐Ketothioamides From α‐Nitroketones, Amines or DMF and Elemental Sulfur Under Oxidant‐Free Conditions
Zhenlei Zhang, Jiusi Yang, Renjie Yu, Kairui Wu, Jiping Bu, Shaoke Li, Peng Qian, Liang-Quan Sheng
Abstract
Abstract We have developed a practical, general protocol for denitration of readily available α‐nitroketones with sulfur and amines to access a broad range of α‐ketothioamides under mild conditions. Such a reaction proceeds under metal‐, oxidant‐, and catalyst‐free conditions to provide synthetically useful α‐ketothioamides. Furthermore, the mild reaction conditions tolerate a wide range of substrates especially for the synthesis of aliphatic α‐ketothioamides which are rarely reported.
Topics & Concepts
ChemistrySulfurReaction conditionsCatalysisOrganic chemistryCombinatorial chemistrySynthesis of heterocyclic compoundsSulfur-Based Synthesis TechniquesSynthesis and Reactivity of Sulfur-Containing Compounds