Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment
Margaret E. Maes, Gabriele M Wögenstein, Gloria Colombo, Raquel Casado-Polanco, Sandra Siegert
Abstract
mouse line. Together, our results provide a foundation for future studies optimizing AAV-mediated microglia transduction and highlight that environmental conditions influence microglial transduction efficiency.
Topics & Concepts
MicrogliaChemistryCell biologyNeuroscienceBiologyInflammationImmunologyNeuroinflammation and Neurodegeneration MechanismsRetinal Development and DisordersNeuroscience and Neuropharmacology Research