<scp>l</scp>-Proline-catalyzed regioselective C1 arylation of tetrahydroisoquinolines through a multicomponent reaction under solvent-free conditions
Iftakur Rahman, Bhaskar Deka, Ranjit Thakuria, Mohit L. Deb, Pranjal K. Baruah
Abstract
Here we disclose the C1 arylation of tetrahydroisoquinolines (THIQ) through regioselective C(sp3)-H functionalization using a multicomponent reaction. The reaction was performed by reacting THIQ, aldehydes and aminopyrazoles or indoles under neat conditions with l-proline as a catalyst. The regioselectivity of the products was confirmed by X-ray analysis and spectroscopic data. The formation of an azomethine ylide intermediate is crucial for obtaining the regioselectivity.
Topics & Concepts
RegioselectivityProlineCatalysisChemistrySolventOrganic chemistryCombinatorial chemistryMedicinal chemistryAmino acidBiochemistryCatalytic C–H Functionalization MethodsMulticomponent Synthesis of HeterocyclesCatalytic Cross-Coupling Reactions