Discovery of novel 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines as ATR inhibitors based on structure-based drug design
Yinliang Qi, Kun Wang, Bin Long, Hao Yue, Yongshuo Wu, Dexiao Yang, Minghui Tong, Xuan Shi, Yunlei Hou, Yanfang Zhao
Topics & Concepts
ChemistryOlaparibCisplatinDrugPharmacologyIC50PyrimidineLead compoundStereochemistryIn vitroBiochemistryDNAPoly ADP ribose polymerasePolymeraseChemotherapySurgeryMedicineDNA Repair MechanismsCancer therapeutics and mechanismsCell death mechanisms and regulation