A thermosensitive hydrogel formulation of phage and colistin combination for the management of multidrug-resistant <i>Acinetobacter baumannii</i> wound infections
Subhankar Mukhopadhyay, Kenneth K.W. To, Yannan Liu, Changqing Bai, Sharon Shui Yee Leung
Abstract
antibacterial efficacy of the F5 hydrogel formulation was also investigated in a pork skin wound infection model, where it significantly reduced the bacterial burden by 4.65 log. These positive outcomes warrant its further development as a topical PAS-wound dressing.
Topics & Concepts
ColistinAcinetobacter baumanniiMicrobiologyPhage therapyBiofilmAntibioticsBacteriaSelf-healing hydrogelsBacteriophageAcinetobacterMultiple drug resistanceChemistryAntibiotic resistanceBiologyPseudomonas aeruginosaEscherichia coliGeneBiochemistryGeneticsOrganic chemistryBacteriophages and microbial interactionsMicrobial infections and disease researchAntimicrobial Peptides and Activities