Obeticholic acid protects against lithocholic acid-induced exogenous cell apoptosis during cholestatic liver injury
Qian Lu, Yangping Zhu, Changling Wang, Rongmi Zhang, Yingying Miao, Yuanyuan Chai, Zhenzhou Jiang, Qinwei Yu
Topics & Concepts
CholestasisFarnesoid X receptorLithocholic acidObeticholic acidBile acidChenodeoxycholic acidHepatoprotectionLiver injuryUrsodeoxycholic acidApoptosisCYP8B1Taurocholic acidBile Salt Export PumpDeoxycholic acidChemistryPharmacologyBiochemistryInternal medicineCholesterol 7 alpha-hydroxylaseMedicineNuclear receptorReceptorGlutathioneAgonistTransporterGeneTranscription factorEnzymeDrug Transport and Resistance MechanismsLiver Diseases and ImmunityDrug-Induced Hepatotoxicity and Protection